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Administration of indinavir with a high-fat meal markedly reduces the rate and extent by approximately 35 to 75 of drug absorption; however, food has little effect on indinavir pharmacokinetics when the drug is administered with a low dose of ritonavir.

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Cardiovascular Systemcardiovascular disorders including myocardial infarction and angina pectoriscerebrovascular disorder.

Concomitant use of CRIXIVAN with lovastatin or simvastatin is contraindicated due to an increased risk of myopathy including rhabdomyolysisCaution should be exercised if CRIXIVAN is used concurrently with atorvastatin or rosuvastatinTitrate the atorvastatin and rosuvastatin doses carefully and use the lowest necessary dose with CRIXIVANSee PRECAUTIONSDRUG INTERACTIONS

Because of the complex regimens and side effects associated with the use of indinavirthis drug is rarely used in Canada and other high-income countriesStillif indinavir is prescribed in Canadahere is some information.

If you must take a drug that has the potential to interact with your existing medicationsyour doctor can do the following:

In both sets of studiesmilk thistle and vitamin Csubjects were taking indinavir as the sole PI in their regimenResults may be different when indinavir is taken in combination with other PIssuch as ritonavir.

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, ketoconazole, itraconazole, ritonavir, indinavir, saquinavir, erythromycin, and cyclosporine can increase systemic budesonide concentrations see clinical pharmacology 12.

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