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Clopidogrel requires hepatic biotransformation to an active metabolite; the activation is thought to be mediated by the cyp3a4 isoenzyme.

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LovastatinMevacorpravastatinPravacholsimvastatinZocorfluvastatinLescolrosuvastatinCrestorand atorvastatinLipitorAll these increase the risk of a condition called rhabdomyolysismuscle injurythat when severe can lead to kidney damage and even deathRhabdomyolysis may occur as early as three weeks or several months after starting combination therapyThe benefit of combining gemfibrozil with statins does not outweigh the risk of rhabdomyolysis.

The effect of gemfibrozil in pregnant women has not been well-studiedGemfibrozil should be used during pregnancy only if the potential benefit justifies the unknown but potential risk to the fetus.

You should tell your doctor if you have liverkidneyor gallbladder disease before taking gemfibrozilIf you have a history of gallstonesyou should also tell your physician.

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ticlopidine may lead to a very low white blood cell count or an immune disorder that destroys platelets.

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